課程大綱

課程資訊

課程名稱

光學診斷技術
Optical Techniques in Diagnosis

開課學期

111-1

授課對象

電機資訊學院光電工程學研究所

授課教師

宋孔彬

課號

BEBI7004

課程識別碼

945 M2900

班次

學分

3.0

全/半年

半年

必/選修

選修

上課時間

星期三2,3,4(9:10~12:10)

上課地點

明達303

備註

總人數上限：18人

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課程概述

Biomedical optics has been increasingly applied to the screening, surveillance and diagnosis of diseases, as well as the non-invasive monitoring of physiological status of tissue/organs in vivo. The interaction between light and biological tissue involves mainly scattering and absorption, which can be modeled analytically with the framework of the Radiative Transport Equation (RTE) or numerically with the Monte Carlo method. With sufficient understanding and appropriate modeling of light-tissue interactions, the clinically relevant and useful information can be extracted from optical signals measured from tissue. The following techniques will be introduced:
1. Diffuse reflectance spectroscopy (DRS) and imaging
2. Near-infrared spectroscopy (NIRS) and tomography
3. Tissue oximetry using DRS or NIRS
4. Fluorescence spectroscopy
5. Single (few) scattering techniques
6. Raman scattering spectroscopy
Other optical techniques related to the non-invasive diagnosis or monitoring of physiological conditions will be reviewed by the students (topics chosen by the students). Note that techniques using only ballistic photons to provide signals (e.g. confocal microscopy and non-linear microscopy) are NOT covered in this course.

課程目標

To obtain the fundamental knowledge and skills for the analysis and interpretation of data measured from tissue, the following steps will be employed:
1. The principle of light propagation in soft tissue will be introduced.
2. Students will learn the practical use of the Monte Carlo method to numerically simulate light propagation in soft tissues.
3. The students will review the literature on selected optical techniques that can be used to aid the non-invasive diagnosis of disease or monitoring of physiological status.
4. Students will get hands-on experience with Monte Carlo simulations or the RTE framework by working on a term project with a topic related to optical diagnostic techniques.

課程要求

1. Homework (individual)
Each student will develop a computer program using the Monte Carlo method to simulate the propagation of photons in biological tissues. Seven sets of computer assignments will be given to gradually guide the students through the model development process. Basic programming ability or acquaintance with Matlab is required.
Alternatively, students can choose Track 2 in which they submit a progress report (with the same due date as the homework) instead of the computer homework.
2. Literature review (individual)
To gain a more in-depth understanding of a selected technique, each student is required to pick a specific topic, study related literature, and make an oral presentation to introduce the selected topic. In addition, students are expected to participate in discussion.
3. Term project
Students will apply the simulation method they have learned in class to improve the data interpretation/analysis or experimental design, or to address a specific question related to optical diagnosis/monitoring of disease/physiology.
Students who choose Track 2 are required to prepare a draft for submitting to a conference or a journal.

預期每週課後學習時數

Office Hours

另約時間

指定閱讀

參考書目

1. "Biomedical Optics: Principles and Imaging", by Lihong V. Wang and Hsin-i Wu. Wiley-Interscience, 2007.
2. "Tissue Optics: light scattering methods and instruments for medical diagnosis”, by Valery Tuchin. Bellingham, Washington: SPIE Press, 2007.
3. "Handbook of Biomedical Optics", edited by David A. Boas, Constantinos Pitris, Nimmi Ramanujam. CRC Press, 2011.
4. "Handbook of Optical Biomedical Diagnostics”, edited by Valery Tuchin. Bellingham, Washington: SPIE Press, 2016.
5. "Optical-Thermal Response of Laser-irradiated Tissue", edited by Ashley J. Welch and Martin J.C. van Gemert. New York: Plenum Press, 1995.

評量方式
(僅供參考)

No.	項目	百分比	說明
1.	程式作業	40%	以蒙地卡羅法模擬光子能量在生物組織中傳遞
2.	期末專題	40%	個人或2人一組，應用組織光學數值模型，分析實際的光學診斷技術，或是改進蒙地卡羅法之實現。繳交書面報告(含模擬結果)
3.	期末專題提案	10%	以口頭與書面形式進行提案，並與授課教師討論
4.	文獻探討	10%	口頭報告，選擇一光學診斷技術，介紹原理、發展近況、可能的應用等。

針對學生困難提供學生調整方式

上課形式	以錄影輔助
作業繳交方式	延長作業繳交期限
考試形式
其他

課程進度

週次	日期	單元主題
第1週		Overview
第2週		Elastic scattering of biological tissue
第3週		Monte Carlo simulation I
第4週		Monte Carlo simulation II
第5週		Radiative transport equation (RTE)
第6週		# Oral presentations - literature review Radiative transport equation (RTE) & analytical solution based on diffusion approximation
第7週		Monte Carlo simulation III
第8週		Monte Carlo simulation IV
第9週		Monte Carlo simulation V
第10週		Diffuse reflectance spectroscopy
第11週		Monte Carlo techniques for DRS functional Near-Infrared Spectroscopy (fNIRS)
第12週		Probe geometry considerations
第13週		Fluorescence spectroscopy, Raman scattering spectroscopy # Project discussion
第14週		# Project proposal (oral presentations)
第15週		# Project progress discussion (oral presentations)
第16週		# Term project mock report (written), no class